-Glutamylcysteine Ethyl Ester Protection of Proteins From A (1–42)-Mediated Oxidative Stress in Neuronal Cell Culture: A Proteomics Approach
نویسندگان
چکیده
Debra Boyd-Kimball, Rukhsana Sultana, H. Fai Poon, Hafiz Mohmmad-Abdul, Bert C. Lynn, Jon B. Klein, and D. Allan Butterfield* Department of Chemistry, Center for Membrane Sciences, University of Kentucky, Lexington, Kentucky Core Proteomics Laboratory, University of Kentucky, Lexington, Kentucky Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Kidney Disease Program and Proteomics Core Laboratory, University of Louisville School of Medicine and VAMC, Louisville, Kentucky
منابع مشابه
-Glutamylcysteine Ethyl Ester-Induced Up-Regulation of Glutathione Protects Neurons Against A (1–42)-Mediated Oxidative Stress and Neurotoxicity: Implications for Alzheimer’s Disease
Glutathione (GSH) is an important endogenous antioxidant found in millimolar concentrations in the brain. GSH levels have been shown to decrease with aging. Alzheimer’s disease (AD) is a neurodegenerative disorder associated with aging and oxidative stress. A (1–42) has been shown to induce oxidative stress and has been proposed to play a central role in the oxidative damage detected in AD brai...
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